Aggravation of viral hepatitis by platelet-derived serotonin
نویسندگان
چکیده
منابع مشابه
Platelet-derived serotonin links vascular disease and tissue fibrosis
Vascular damage and platelet activation are associated with tissue remodeling in diseases such as systemic sclerosis, but the molecular mechanisms underlying this association have not been identified. In this study, we show that serotonin (5-hydroxytryptamine [5-HT]) stored in platelets strongly induces extracellular matrix synthesis in interstitial fibroblasts via activation of 5-HT(2B) recept...
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Abstract Background and Objectives Platelets release microparticles containing cellular components, including microRNAs, during storage. Assessment of these microRNAs is one of the markers for evaluation of platelet storage lesions. The aim of the present study was to evaluate the level of changes in the expression of mir-223, mir-92a and mir-222 during storage in platelets prepared by platele...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2008
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm1780